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Bioinorganic chemistry is a leading discipline at the interface of chemistry and biology. Many critical processes require metal ions, including respiration, much of metabolism, nitrogen fixation, photosynthesis, development, nerve transmission, muscle contraction, signal transduction. Unnatural metals have been introduced into human biology as diagnostic probes and drugs. First consider which metalions are used in living organisms, why nature might have chosen them, how they get into cells, and how their concentrations are regulated. We next discuss how metals bind to biopolymers, how metal binding can fold biopolymers. Ieading to function, and how they are inserted into their active centers. This book should appral to members of the medical as well as chemical and bioogical communities. * Contents : Overview of bioinorganic chemistry. principles of coordination chemistry related to bioinogranic research. Properties of biological molecules. Physical methods in bioinorganicchemistry. Choice, uptake, and assembly metal containing units in biology. Control and utilization of metalion concentration in cels. Metal ion folding and cross linking of biomolecules. Binding of metal ions and complexes to nbiomolecule-active centers. Electron- transfer protieins. Substrate binding and activation by nonredox mechanisms. Atom-and group-transfer chemistry. Protein tuning of metal properties to achieve specitfic functions. The frontiers of bioinorganic chemistry. Index. 1997 PB
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