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This monograph addresses, in a systematic and pedagogical manner, the mathematical methods and the algorithms required to deal with the molecularly based problems of bioinformatics. The book will be useful to students, research scientists and practitioners of bioinformatics and related fields, especially those who are interested in the underlying mathematical methods and theory. Among the methods presented in the book, prominent attention is given to pair-wise and multiple sequence alignment algorithms, stochastic models of mutations, modulus structure theory and protein configuration analysis. Strong links to the molecular structures of proteins, DNA and other biomolecules and their analyses are developed. In particular, for proteins an in-depth exposition of secondary structure prediction methods should be a valuable tool in both molecular biology and in applications to rational drug design. The book can also be used as a textbook and for this reason most of the chapters include exercises and problems at the level of a graduate program in bioinformatics.
Table of Contents
Part I : Mutations and Alignments
Introduction
Stochastic Models of Mutations and Structural Analysis
Modulus Structure Theory
Super Pairwise Alignment
Multiple Sequence Alignment
Network Structures of Multiple Sequences Induced by Mutation
Alignment Space
Part II : Protein Configuration Analysis
Background Information Concerning the Properties of Proteins
Informational and Statistical Iterative Analysis of Protein Secondary Structure Prediction
Three-Dimensional Structure Analysis of the Protein Backbone and Side Chains
Alignment of Primary and Three-Dimensional Structures of Proteins
Depth Analysis of Protein Spatial Structure
Analysis of the Morphological Features of Protein Spatial Structure
Semantic Analysis for Protein Primary Structure
ISBN - 9788184896251
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Pages : 464
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