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Vitamin E is an important dietary constituent which helps in the defence against cellular damage. The absorption of Vitamin E from food and its utilization by the body is an intricate series of reactions and has been shown to be an important factor in preventing heart disease and cancer. Vitamin E is also used therapeutically in treating numerous diseases and conditions such as skin damage and in the prevention of pathological lesions in major organs.
The encyclopedia has over 80 chapters from international contributors which makes it the most comprehensive reference work describing both the positive and negative effects and actions of Vitamin E. Chapters are divided into subsections which cover: nomenclature and biochemical, physical and chemical aspects of vitamin E-related compounds: dietary and nutritional influences and effects; cocktails, anti-oxidant mixtures and novel analogues; general physiological systems, metabolism and metabolic stress; brain, neurological and optical systems; reproductive systems, fetuses and infants; musculo-skeletal systems and exercise; cardiovascular and pulmonary systems; skin; hepatic and gastrointestinal systems; immune and haematological systems; and cencer. This book will be of significant interest to those studying nutrition, food science, medicine and biochemistry.
Contents : • Preface • Acknowledgments • Part 1: Nomenclature and Biochemical, Physical and Chemical Aspects of Vitamin E-related Compounds • Overview of Antioxidant of Vitamin E • Vitamin E, Metabolism and Biological Activity of Metabolic Products • PMC -2, 2, 5, 7, 8 - Pentamethy - Chroman 6-ol and Related Model Compounds • Recycling of Vitamin E by Natural Products: a Dietary Perspective • Mossbauer Spectroscopy Studies of Tocopherol • Chemical Modifications of Alpha - Tocopherol • Functions and Activities of Tocotrienols and Tocopherols In Vitro • An Overview of Free Radicals and Oxidative Stress: Setting the Scene • Tocopherol Composition of Plants and Their Regulation • Efficiency of Extracting Vitamin E from Plant Sources • Commercial Extraction of Vitamin E from Food Sources • Overview of Tocopherol Composition of Oils • Changes in Tocopherol Composition of Edible Oils after Extreme Heat Exposure (frying) • Analysis of Vitamin E by HPLC • Capillary Electrochromatographic Analysis of Tocopherols • GC-MS and LC-MS/MS Techniques to Quality Alpha-Tocopherol and Alpha-Tocopherolquinone Applications to Biological and Food Matrices • Assay of Free Radical- Generated Cholesterol Metabolites and Alpha-Tocopherol in Plasma and Tissues • Interactions of Vitamin E with Biomembrane Models: Binding to Dry and Water-Containing Reversed Micelles • Part II: Dietary and Nutritional Influences and General Effects • Vitamin E Bioavailability • Circulating Concentrations of Vitamin E in Populations • The Relationship Between Tocotrienols and Tocopherols in the Diet • The Relationship Between Alpha-Tocopherol and Selenium in the Diet • The Relationship Between Alpha-Tocopherol, Selenium and Fish Oil in the Diet and Effects on the Heart and Liver • Vitamin E Status in the Elderly • Part III: Cocktails, Antioxidant Mixtures and Novel Analogues • Efficacy of Tocopherol Mixtures Compared with Alpha-Tocopherol in Cardioprotection • Hyperlipidaemia and the Use of Tocopherol in Antioxidant Cocktails in Smokers • Part IV: General Physiological Systems, Metabolism and Metabolic Stress • Tissue Distribution of Alpha-Tocopherol in Oxidative Stress in Rats • Cellular Metabolism in Vitamin E Deficiency • Role of Vitamin E Vitamin C in Nuclear Factor -B- Dependent Nitric Oxide Signalling • Modification of the Activation of NF-B-by Vitamin E • Vitamin E and Cell Signalling • Vitamin E Supplementation in Diabetes Mellitus • Serum Alpha-Tocopherol and Insulin Therapy in Diabetes: Relationship to Retinol • Lead-Induced DNA Damage and Relationship with Vitamin E • Alpha-Tocopherol and Surgical Stress • Ischaemia-reperfussion Injury and Tocopherols • Part V : Brain, Neurological and Optical Systems • Vitamin E Cocktails and Their Preventive Effects on the Retina in Type 1Diabetes • Neuronal Damage, Cognitive Impairment and Alpha-Tocopherol • Vitamin E Coenzyme Q10 in Parkinson’s Disease • Protective Effects of Alpha-Tocopherol on Nicotinic Acetylcholine Receptors in Alzheimer’s Disease • Effects of Vitamin E on the Apoptotic Cascade: Studies in Neuronal Cells • Effects of Vitamin E on the Brain in Diabetes • Part VI : Reproductives Systems, Fetus and Infant • Alpha-Tecopherol and Male Fertility • Alpha-Tocopherol and Pre-eclampsia • Alpha-Tocopherol and Antioxidant Status in Premature Infants • Alpha-Tocopherol in Infants and Relationship with the Mothers • Transfer of Vitamin E in Milk to the Newborn • Improving Thin Endometrium by Combined Pentoxifylline_Tocopherol Treatment if Fibrosis is Present • Part VII : Musculo-Skeletal Systems and Exercise • Vitamin E Uncouples Joint Destruction and Clinical Inflammation in a Transgenic Mouse Model of Rheumatoid Arthritis • The Effect of Vitamin E on post Exercise Fatigue • Post-Contraction Damage to muscle and Vitamin E • Muscle Damage after Running and Effects of a Vitamin E and C Cocktail • Part VIII : Cardiovascular, Haematological and Pulmonary Systems • Alpha-Tocopherol and Vascular Endothelial Growth Factor • Alpha-Tocopherol and Adhesion Molecules in Endothelial Cells • Overview of Vitamin E and Human Low-Density Lipoprotein • Alpha-Tocopherol in Lipoprotein Apheresis • Smooth Muscle Cells and Alpha-Tocopherol • Vitamin E and Atherosclerosis • Vitamin E and Blood Pressure • Vitamin E and Platelets • Vitamin E and the Lunge: Uptake Mechanism and Function in Alveloar Type II Cells • Smoking and Tocopherol Status • Failure of Alpha-Tocopherol to Prevent Cigarette Smoke-Induced Protein Oxidation: Comparison with other Antioxidant Vitamins • Protective Effects of Alpha-Tocopherol in Pulmonary Fibrosis • Alpha-Tocopherol and Cystic Fibrosis • Hypoxia-Induced Lung Damage and Alpha-Tocopherol • Part IX : Skin • Overview of Alpha-Tocopherol and the Skin • The Skin and Vitamin E Cocktails • Relationship Between Alpha-Tocopherol and Glutathione in Keratinocytes • Part X : Liver, Kidney, Intestinal and Other Organ Systems • Alcoholic Liver Disease, Oxidative Stress and the Role of Tocopherol • Liver Cirrhosis and Vitamin E Status • Inflammatory Bowel Disease and Oxidative Stress: Role of Vitamin E • Vitamin E, Gastric Pathology and Helicobacter pylori: Causes and Relationships • Does Oxidative Stress in Haemodialysis Patients Require an Overprotection with Vitamin E Supplementation? • Part XI : Immune and Haematological Systems • Natural Forms of Vitamin E as Anti-Inflammatory and Anti-Cancer Agents: Their Effect on Cyclo-Oxygenase and Other Membrane-Associated Enzymes • Vitamin E and Its Effects on Macrophages and Neutrophils • Vitamin E in Relation to Other Antioxidants in HIV Disease • Vitamin E and Hepatic Effects of Cycloporins • Mycotoxins and Protection with Vitamin E • Alpha-Tocopherol and Expression of the CD95 Ligand • Part XII : Cancer • Overview of Tocopherols in Cancer Chemoprevention • Chemical and Biological Properties of Tocopherols and their Relation to Cancer Incidence and Progression • Cancer Progression and Alpha-Tocopherol in Relation to Other Antioxidants • Chemoprevention and Vitamin E with or Without Selenium • Effects of Dietary Vitamin E on Mutatect Tumours• Tocopherols and Lung Cancer • Gastrointestinal Cancers and Vitamin E • Alpha-Tocopheryl Succinate Exhibits Potent Anticancer Activity: its Interaction with Ionizing Radiation and Chemotherapeutic Effects • Index.
ISBN - 1845930754
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Pages : 980
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